[(8β)-1,6-Dimethylergolin-8-yl)methyl]carbamicacidphenylmethylester

Name	METERGOLINE
Synonyms	Lyserdol liserdol METERGOLINE n-cbz-[(8β)-1,6-dimethylergolin-8-yl]methylamine N-[(1,6-Dimethylergolin-8β-yl)methyl]carbamic acid benzyl ester [(8β)-1,6-Dimethylergolin-8-yl)methyl]carbamicacidphenylmethylester [((8beta)-1,6-Dimethylergoline-8-yl)methyl]carbamic acid phenylmethyl ester D-[(4,6,6a,7,8,9,10,10a-Octahydro-4,7-dimethyl-10aalpha-indolo[4,3-fg]quinolin-9beta-yl)methyl]carbamic acid benzyl ester N-Cbz-[(8β)-1,6-Dimethylergolin-8-yl]methylamine, [(8β)-1,6-Dimethylergolin-8-yl)methyl]carbamic acid phenylmethyl ester
CAS	17692-51-2
EINECS	241-686-3
InChIKey	WZHJKEUHNJHDLS-QTGUNEKASA-N

Molecular Formula	C25H29N3O2
Molar Mass	403.52
Density	1.25±0.1 g/cm3(Predicted)
Melting Point	148-150°C(lit.)
Boling Point	612.5±55.0 °C(Predicted)
Specific Rotation(α)	D28 -7 ±2°
Solubility	0.1 M HCl: 1.4mg/mL
Appearance	solid
Color	White
Merck	13,5962
pKa	12.45±0.46(Predicted)
Storage Condition	−20°C
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethaqnol may be stored at -20°C for up to 2 month.
In vitro study	Metergoline (3 μM) causes a 6.8±1.2 mV depolarizing shift of the steady-state activation curve of the Na + currents, and do not alter the inactivation curve.

Hazard Symbols	Xn - Harmful
Risk Codes	20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description	36 - Wear suitable protective clothing.
WGK Germany	3
RTECS	FA1070000
Toxicity	LD50 in mice (mg/kg): 85 i.p., 430 orally; in rats (mg/kg): >800 orally (Beretta)

Last Update：2024-01-02 23:10:35

biological activity	Metergoline is a serotonin (5-HT) receptor and dopamine receptor antagonist, which, the pKi values for the effects of 5-HT2B and 5-HT2C were 8.64, 8.75 and 8.75, respectively. Metergoline is a high affinity ligand for the h5-HT7 receptor with a Ki of 16 nM. Metergoline is also a reversible inhibitor of neuronal Na channels. Metergoline is commonly used to study seasonal affective disorder, Prolactin regulation.
Animal Model:	Male albino mice (25-40 g)
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection
Result:	Inhibited bites or scratches induced by 5-HT (2 μg).

Last Update：2024-04-09 21:01:54

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CAS: 17692-51-2
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